"Should stop for a break every X miles or Y time anyway" is a personal take.
An HGV driver can legally drive for 4.5 hours without taking a break. Driving an HGV is more demanding than driving a car. Air traffic controllers are allowed to be on duty for 2 hour stints. I doubt driving just a car should require that much mental focus / strain.
I personally have no problem driving 350 miles while towing the caravan or boat, I might stop to use the toilet at a services but that's all. It is more taxing driving while towing the caravan or boat than it is driving when not towing, 350 miles without a break when not towing is no problem at all.
I really wouldn't want to have 'breaks' enforced on me by lack of vehicle range and long recharge times. When I've owned petrol cars that had less than 250 miles range in the past I stopped to refuel on longer drivers but refuelling only took a few minutes, I refuelled, paid, and set off again immediately.
Sometimes when range is discussed EVers say "You should be taking a M minute break every X hours of driving anyway, your car can be recharging during that time". I think well maybe you need M minutes break every X hours of driving, I have no problem driving for X + 2 hours without a break and M minutes would be at least inconvenient. Not to mention that if I towed with an EV that had supposed R range the actual range while towing would be much lower than R and I'd have multiple M sessions imposed on me by the car. Then for some places I go there would be nowhere to recharge at the destination.
When I was a kid I used to like the Logan's Run TV series and particulary like the electric hover cars. I knew it wasn't possible to make anything like the hover car but I used to build 'trolleys' (soap box cars) using pram wheels and wanted to make one that was battery powered and could carry a few mates. We used to take trolleys all over the place, call around for other friends who lived a couple of miles away by pulling them along the causeway (or ride on them on downhill strteches). It seemed it'd be OK and legal to drive an electric powered trolley carrying a few mates along causeways all the way to the seaside hehe. I imagined using a car engine starter motor and car battery(s). My dad said the starter motor would overheat and flatten the battery(s) too quick, I worked out that a few car windscreen wiper motors suitably geared and multiple car batteries would do quite a few miles in theory but the mutiple batteries would be heavy and we'd need to upgrade to proper wheels. If we took our own battery charger we could charge wherever there was electricity and at that time you could prise off the cover from most street lights and tap into power from them so we'd always be able to get a charge even in the case we were daring enough to knock on people's doors to ask if we could plug our trolley in for a charge and nobody let us. Besides the engineering problems (when you're a young kid) other problems included the weight and cost of the batteries and the amount of time we'd be camped out beside a power point waiting for the recharge. I discussed all this with dad who told me a pint of petrol has more power than all the car batteries I could carry on a trolley and I could instead think about fitting a little engine on the trolley and carrying just a gallon of petrol, less weight and more sustained power over longer ranges. I liked the engine idea but at the time it seemed it'd be illegal to drive something engine powered on the causeway but legal to drive something electric powered. The trolley I was thinking about would be like a little campervan made of wood with a roof etc, me and my mates inside and seats would change into bunk beds. I never did make anything like the camper trolley or battery powered but I did convert an old go-kart to be powered by an old electric sewing machine 240v motor using some kind of little gearbox dad had knocking around. The problem with the 240v go-kart was the extension lead running from the garage to the go-kart severely limiting range and getting tangled hehe. Dad seemed willing to help us fit an engine on a trolley but nothing came of it, he did help us get as far as fitting proper steering with a steering wheel to one trolley instead of having the usual rope steering setup. Looking back it seems some of the problems I was trying to solve back then totally went away when I was old enough to start thinking about driving proper cars with engines, no need to think about carrying mates in a trolley on causeways when you know you'll soon be old enough to have a real car and drive it on motorways etc, then it all seemed to come back again with the rise of EV's and all the concerns are now mainstream talking points rather than just slightly nerdy kid interest points lol. The problem for me would still be range and long charge times, especially when towing. Also if it's no cheaper to recharge an EV away from home than to refuel my car away from home I'd be spending money on a more expensive EV while not benefitting from cheaper per mile fuel costs.