As mentioned above there are videos on removing the buddy bottle, this also applies to other bottle guns like the S10.
The first 2 minutes of this video answers the first question.
The rest of the video will help with your seal replacement, there are specific videos on R10 reg service
The amount of turns of the bottle to release the air depends on the setting of the pin that depresses the valve in your bottle, this can be a fiddle to set from scratch so if working, leave alone.
There's no test on bottles of this size as discussed elsewhere on the forum. Check for any obvious signs of damage and it should be fine. If you spot damage or are uncomfortable with it's age there are replacements readily available.
What an amazing PCP to start with! You'll never 'need' to change it.
Over time seals will fail the same as any other PCP, the seal on your reg piston will turn into a hard carbon ring then the reg will fail. This can be avoided by preventative maintenance / seal replacement throughout. All parts are available and inexpensive.
Overtime the brass parts may develop green corrosion. Check inside the bottle valve, this can prevent the valve from seating and cause a leak there and your fill port assembly, there is a ball sat on an o-ring for the none return valve with a brass fitting that houses a spring and plunger corrosion here can make the spring and plunger stick and leak from the fill port.
The brass in the regulator and firing valve assembly doesn't seem to get affected to the same degree probably due to moisture condensating on the first coldest surfaces it comes in to contact with as you fill.
Easily fixed by removing the green corrosion with Scotch-Brite or similar.