Assuming you mean MOA vs mrad/mil there is quite a big difference but normal folk like us don't take any advantage of it. Radians and milliradians are actually a measure of distance (
see here) and have been used by militaries for years to work out artillery ranges etc and are part of their language.
Early telescopic sights were simple wire and post affairs superseded in the civilian world by MOA based designs so for example while the Leupold duplex doesn't use MOA graduations the distance between wire and post and post thickness are all measured in MOA. Of course we do have fully graduated MOA scopes now and it was natural that the 1/4 MOA click became the standard.
However MOA didn't suit the military, if snipers only shot people it probably wouldn't make much difference but snipers also spend a lot of time watching people and making notes on what they see. It made sense to use mildots for their reticles so they could take accurate measurements and then transmit them back in the common tongue, hence the mildot reticle was born in the USA and adopted in the UK around 1988. We were aware of the adjustment click issue when using the new dots so the new Scmidt and Bender L17A1 scope for the Accuracy International Arctic Warfare rifle used 1/10 MOA clicks as do all military scopes now.
Of course with the Mil(itary) Dot scopes "tactical" credentials the manufacturers were happy to sell them to us and we were happy to buy them for their numerous aim points in a standardised format. They were less happy to match the adjustment clicks and as we were not doing so much long range shooting back then we didn't really notice, but it is becoming more of an issue now. I prefer MOA but simply because I think in inches, people with my impediment will soon die out so I guess mildots really are the way forward but only with the correct adjustments. But for pity's sake, not on compasses please...
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